Demyelinating Disease Models of Central Nervous System Mechanisms of Immunopathology in Murine

Mechanisms of immunopathology in murine models of central nervous system demyelinating disease.

Many disorders of the CNS, such as multiple sclerosis (MS), are characterized by the loss of the myelin sheath surrounding nerve axons. MS is associated with infiltration of inflammatory cells into the brain and spinal cord, which may be the primary cause of demyelination or which may be induced secondary to axonal damage. Both the innate and adaptive arms of the immune system have been reporte...

O 14: Differentiating Demyelinating Disorders of the Central Nervous System – a Focus on Multiple Sclerosis and Neuromyelitis-Optica Spectrum Disorders

Significant advances have been made in diagnosis and therapy of demyelinating disorders of the central nervous system. The most common entities of this disorders in adults – multiple sclerosis and neuromyelitis optica were initially thought to be different phenotypes of more or less the same disease. During the last ten years, this view was subsequently changed and the term neuromyelitis ...

Is Hemorrhagic Demyelinating Lesions of Central Nervous System a Spectrum?

Cross-talks between the kidneys and the central nervous system in multiple sclerosis

Multiple sclerosis (MS) is an inflammatory demyelinating disease, which is considered as a common autoimmune disorder in young adults. A growing number of evidences indicated that the impairment in non-neural tissues plays a significant role in pathology of MS disease. There are bidirectional relationship, metabolic activities and functional similarity between central nervous system (CNS) and k...

Review of New Methods of Diagnosis and Treatment of Multiple Sclerosis

Multiple sclerosis (MS) is a demyelinating process involving mainly the white matter of central nervous system. The clinical diagnosis generally rests on two features of the illness:  A. A history of fluctuations in the clinical course. B. A physical examination consistent with that of multiple lesionsjinllheiwhite matter o,f the central nervous system.  No specific laboratory test is cur...